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There is an ITS Duo support site that has all of the information that you will need to get enrolled for using Duo. Please direct all questions regarding enrollment to the ITS Help Desk, whose contact information is listed on the Duo support site. The most convenient method for managing Duo, particularly on the HPC systems, is via Duo's app for smartphones. There is support for all, or most, types of smart phones. The use of a smartphone is needed to ; see this page for more information.
Once you are enrolled in Duo you are ready to use it on the HPC systems. Usage is fairly straight forward and is very similar to what you may be accustomed to with Web sites, such as the UIowa Employees Self Service site. All of the authentication methods are supported however, given that the HPC systems are shell systems, the duo-push method is very convenient for automation.